Genomics Research and Sequencing Service
Our institute provides comprehensive genomics services, including whole-genome sequencing (WGS), single-cell sequencing, transcriptome profiling, and targeted sequencing for cancer and oncology research, coupled with advanced bioinformatics analysis.
Genomics Services Offered:
Custom Bioinformatics Analysis
Targeted Sequencing (Cancer/Tumor Panels)
Transcriptome Sequencing (RNA-Seq)
Single-Cell Sequencing
Whole-Genome Sequencing (WGS)
🧬 Single-Cell Sequencing Services
Unlocking Cellular Heterogeneity with High-Resolution Single-Cell Genomics
At HLA Institute, we provide cutting-edge single-cell sequencing services designed to decode cellular complexity at the resolution of individual cells. Leveraging industry-leading platforms, we deliver high-throughput single-cell transcriptome (scRNA-seq), immune profiling (TCR/BCR), and multi-omics solutions that overcome the limitations of bulk sequencing. Our services empower researchers to dissect cellular heterogeneity, identify rare cell populations, and map dynamic cellular trajectories in complex biological systems.
From sample preparation and library construction to advanced bioinformatics analysis, we offer end-to-end support for studies in hematopoietic stem cell transplantation, tumor microenvironment profiling, xenotransplantation immunology, and precision medicine. Whether you require discovery-driven exploratory research or clinically relevant validation, our single-cell sequencing expertise transforms complex data into actionable biological insights.
Platform & Technology
🧪 Sample Versatility
🧬 Specialized Application Expertise
💻 End-to-End Bioinformatics
Actionable Insights: Delivery of publication-ready figures and biologically meaningful interpretations tailored to your research objectives.
Customized Analysis Pipelines: From raw data processing to advanced downstream analysis, including trajectory inference (pseudotime), cell-cell communication, and integration with HLA genotyping data.
Xenotransplantation Research: High-resolution characterization of cross-species cellular interactions and immune responses in pig-to-human xenotransplantation models.
Oncology Microenvironment: Precise dissection of the tumor microenvironment (TME), identification of rare cell subpopulations, and mechanisms of immune evasion.
Transplant Immunology: Deep experience in analyzing chimerism, GVHD mechanisms, and immune reconstitution post hematopoietic stem cell transplantation (HSCT).
Flexible Sample Types: Expertise in processing diverse sample sources, including fresh/frozen tissues, peripheral blood, bone marrow aspirates, and challenging FFPE specimens.
Multi-Omics Solutions: Integrated analysis covering single-cell transcriptomics (scRNA-seq), immune profiling (TCR/BCR sequencing), and epitope mapping.
Industry-Leading Platforms: Comprehensive support for 10x Genomics workflows and other high-throughput single-cell technologies.
Bioinformation and sevice
"From Raw Reads to Clinical Decisions — Advanced Bioinformatics for Precision Transplant Immunology."
"Core Bioinformatics Capabilities
🔬 Immunogenomics Analysis
🧬 Multi-Omics Integration
🛡️ Transplant & Clinical Genomics
🗃️ Database & Pipeline Development
Secure, HIPAA-compliant data delivery portals
Custom annotation tracks for xenotransplantation research
In-house curated HLA/SLA allele databases
Cross-species (pig-to-human) genomic compatibility scoring
Donor-Specific Antibody (DSA) epitope matching
dd-cfDNA quantification for rejection monitoring
Fusion gene and transcript isoform detection
Tumor somatic mutation & neoantigen prediction
scRNA-seq / scTCR-seq / scBCR-seq pipeline automation
KIR gene diversity and CNV analysis
De novo assembly & phased haplotype reconstruction
High-resolution HLA/SLA typing algorithms (NGS-based)